Lupus

Clinical study of a patient with lupus vulgaris before and after injection of dialyzable transfer factors.

J Invest Dermatol 1977 Jan;68(1):10-5

Horsmanheimo M, Krohn K, Virolainen M.

This report describes the clinical improvement and acquisition of tuberculin skin-test sensitivity by a tuberculin-negative, drug-resistant patient with lupus vulgaris after a single injection of dialyzable transfer factors from a tuberculin-positive healthy donor. The patient's lymphocytes showed a slight response to tuberculin in the leukocyte migration inhibition test and in the lymphocyte transformation test before dialyzable transfer factors injection. The acquisition of cellular immunity to tuberculin was demonstrated in vitro by enhanced tuberculin-induced blast transformation. A good correlation between skin test and in vitro tuberculin sensitivity and clinical improvement was seen during the three years that the patient was observed.

PMID: 318672 [PubMed - indexed for MEDLINE]